BMJ. 1997 May;314(7093):1512-1515. DIGAMI Study Group. CONCLUSION: Insulin-glucose infusion followed by intensive subcutaneous insulin in diabetic patients with acute myocardial infarction improves long term survival, and the effect seen at one year continues for at least 3.5 years, with an absolute reduction in mortality of 11%. This means that one life was saved for nine treated patients. The effect was most apparent in patients who had not previously received insulin treatment and who were at a low cardiovascular risk. 研究目的：观察患2型糖尿病的心肌梗死(AMI)患者用胰岛素积极控制代谢对预后的影响。在糖尿病患急性心肌梗死患者接受胰岛素葡萄糖注射研究（DIGAMI study）中，随机选取620名 24小时前发生心肌梗死的糖尿病患者（其血糖高于11 mmol/L）, 分成二组，一组持续24小时以上接受胰岛素葡萄糖注射，接着皮下注射胰岛素，每日4次，持续3个月，对照组进行常规抗糖尿病治疗。结果强化胰岛素治疗组在入院24小时和出院时血糖控制明显优于标准治疗组，虽然两组住院病死率相似，但在12个月时和平均3.4年的随访中，强化胰岛素治疗组病死率要较标准治疗组低30% (P=0.027)和28% (P=0.011)。表明胰岛素葡萄糖输注和随后继续强化胰岛素治疗可改善长期存活率，这种效果可在1年时见到，且至少延续3.5年，可使死亡率减少11%，在以前未接受胰岛素治疗的病人中这种效果最明显。