JAMA. 2004 Jul 7;292(1):45-54. Enoxaparin vs unfractionated heparin in high-risk patients with non-ST-segment elevation acute coronary syndromes managed with an intended early invasive strategy: primary results of the SYNERGY randomized trial. Ferguson JJ， Califf RM， Antman EM， Cohen M， Grines CL， Goodman S， Kereiakes DJ， Langer A， Mahaffey KW， Nessel CC， Armstrong PW， Avezum A， Aylward P， Becker RC， Biasucci L， Borzak S， Col J， Frey MJ， Fry E， Gulba DC， Guneri S， Gurfinkel E， Harrington R， Hochman JS， Kleiman NS， Leon MB， Lopez-Sendon JL， Pepine CJ， Ruzyllo W， Steinhubl SR， Teirstein PS， Toro-Figueroa L， White H; SYNERGY Trial Investigators.

CONTEXT: Enoxaparin has demonstrated advantages over unfractionated heparin in low- to moderate-risk patients with non-ST-segment elevation acute coronary syndromes (ACS) treated with a conservative strategy.

OBJECTIVES: To compare the outcomes of patients treated with enoxaparin vs unfractionated heparin and to define the role of enoxaparin in patients with non-ST-segment elevation ACS at high risk for ischemic cardiac complications managed with an early invasive approach.

DESIGN， SETTING， AND PARTICIPANTS: The Superior Yield of the New Strategy of Enoxaparin， Revascularization and Glycoprotein IIb/IIIa Inhibitors (SYNERGY) trial was a prospective， randomized， open-label， multicenter， international trial conducted between August 2001 and December 2003. A total of 10 027 high-risk patients with non-ST-segment elevation ACS to be treated with an intended early invasive strategy were recruited.

INTERVENTIONS: Subcutaneous enoxaparin (n = 4993) or intravenous unfractionated heparin (n = 4985) was to be administered immediately after enrollment and continued until the patient required no further anticoagulation， as judged by the treating physician.

MAIN OUTCOME MEASURES: The primary efficacy outcome was the composite clinical end point of all-cause death or nonfatal myocardial infarction during the first 30 days after randomization. The primary safety outcome was major bleeding or stroke. RESULTS: The primary end point occurred in 14.0% (696/4993) of patients assigned to enoxaparin and 14.5% (722/4985) of patients assigned to unfractionated heparin (odds ratio [OR]， 0.96; 95% confidence interval [CI]， 0.86-1.06). No differences in ischemic events during percutaneous coronary intervention (PCI) were observed between enoxaparin and unfractionated heparin groups， respectively， including similar rates of abrupt closure (31/2321 [1.3%] vs 40/2364 [1.7%])， threatened abrupt closure (25/2321 [1.1%] vs 24/2363 [1.0%])， unsuccessful PCI (81/2281 [3.6%] vs 79/2328 [3.4%])， or emergency coronary artery bypass graft surgery (6/2323 [0.3%] vs 8/2363 [0.3%]). More bleeding was observed with enoxaparin， with a statistically significant increase in TIMI (Thrombolysis in Myocardial Infarction) major bleeding (9.1% vs 7.6%， P =.008) but nonsignificant excess in GUSTO (Global Utilization of Streptokinase and t-PA for Occluded Arteries) severe bleeding (2.7% vs 2.2%， P =.08) and transfusions (17.0% vs 16.0%， P =.16).

CONCLUSIONS: Enoxaparin was not superior to unfractionated heparin but was noninferior for the treatment of high-risk patients with non-ST-segment elevation ACS. Enoxaparin is a safe and effective alternative to unfractionated heparin and the advantages of convenience should be balanced with the modest excess of major bleeding.